[Sy-compmolecbio-global] The Sixth Annual BioMaPS/DIMACS Summer School: Chromatin Structure and Gene Regulation
Linda Casals
lindac@dimacs.rutgers.edu
Thu, 8 May 2008 11:08:29 -0400 (EDT)
The Sixth Annual BioMaPS/DIMACS Summer School: Chromatin Structure and Gene Regulation
June 9 - 13, 2008
Life Science Auditorium, Life Sciences Building, Busch Campus, Rutgers University
Organizers:
Alexandre Morozov, Rutgers University, morozovp at physics.rutgers.edu
Vasily Studitsky, UMDNJ, studitvm at umdnj.edu
Presented under the auspices of the DIMACS/BioMaPS/MB Center Special
Focus on Information Processing in Biology. This special focus is
jointly sponsored by the Center for Discrete Mathematics and
Theoretical Computer Science (DIMACS), and the Biological,
Mathematical, and Physical Sciences Interfaces Institute for
Quantitative Biology (BioMaPS). The National Institutes of Health
provides partial funding of the BioMaPS Summer School through the NIH
Roadmap for Medical Research, Grant 5 K07 GM72919.
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Announcement:
The course is a five-day intensive investigation of chromatin
structure and gene regulation divided into two related parts:
1. Basic introduction to chromatin structure and gene regulation for
participants with extensive training in the mathematical,
computational, and physical sciences but with a more limited
background in molecular biology.
2. Advanced reviews of current contributions to the understanding of
the interplay between chromatin structure and gene regulation in
eukaryotic organisms.
The speakers will discuss genomic studies of chromatin aided by modern
high-throughput technologies, histone modifications and signaling,
chromatin remodeling, and how chromatin states are assembled and
maintained in the cell. A separate session will be devoted to
computational studies of chromatin using biophysical and statistical
approaches.
If you would like to present a poster on a related topic during the
Poster Session (afternoon of Wednesday, June 11, 2008) please indicate
in the relevant section of your registration form and provide a title
and abstract. Requests must be approved by the organizers before
presenting a poster. The lectures have been designed to provide
participants with a limited knowledge of biology a smooth transition
to the understanding and appreciation of cutting-edge research on the
interplay of chromatin structure and gene regulation. Tutorial
introductions will be presented at the beginning of each day from
Monday, June 9 through Thursday, June 12, 2008.
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Course Goals and Intended Audience:
This short course on chromatin structure and gene regulation is designed to:
1. enable participants with advanced training in the mathematical,
computational, and physical sciences, but with a more limited
background in biology, to contribute to research at the interface
of the biological, mathematical, and physical sciences;
2. introduce participants with traditional backgrounds in
biochemistry, genetics, and molecular biology to the potential
value of quantitative approaches in their own work;
3. provide participants with in-depth training in an important
subfield within molecular biology.
The course is appropriate for graduate students, post-doctoral
fellows, faculty members, and biomedical researchers from non-academic
organizations.
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Workshop Program:
This is a preliminary program.
June 9, 2008: Chromatin structure and genomic studies of chromatin
Session Chair: Vincent Pirrotta
Morning:
9:20 - 9:30 Introduction and welcoming remarks
Alexandre Morozov & Vasily Studitsky
9:30 - 10:30 Transcriptional regulatory mechanisms and epigenetic inheritance
Kevin Struhl, KEYNOTE SPEAKER, Harvard Medical School
10:30 - 12:00 Intra- and inter-nucleosome interactions of the core
histone tail domains
Jeff Hayes, University of Rochester Medical Center
12:00 - 1:30 Lunch Break
Afternoon:
1:30 - 2:30 Polycomb mechanisms and genomic programming
Vincent Pirrotta, Rutgers University
2:30 - 3:30 Organization of chromatin and the transcription
machinery throughout the yeast and fly genomes
Frank Pugh, Penn State University
3:30 - 3:45 Break
3:45 - 4:45 Chromatin-mediated mechanisms for the regulation of
genome accessibility in yeast, worms, and humans
Jason Lieb, University of North Carolina, Chapel Hill
June 10, 2008: Computational modeling of chromatin states
Session Chair: Wilma Olson
Morning:
9:30 - 10:00 Introduction to the polymer physics of chromatin
Swagatam Mukhopadhyay, Rutgers University
10:00 - 11:00 Epigenetic chromatin silencing
Anirvan Sengupta, Rutgers University
11:00 - 12:00 Flexing and Folding of nucleosome-bound DNA
Wilma Olson & Guohui Zheng, Rutgers University
12:00 - 1:30 Lunch Break
Afternoon:
1:30 - 2:30 Biophysical models of chromatin structure and gene regulation
Alexandre Morozov, Rutgers University
2:30 - 3:30 A new model for the linker histone binding based on
comparative sequence analysis of chicken and yeast nucleosomal DNA
Victor Zhurkin, NIH
3:30 - 3:45 Break
3:45 - 4:45 Prediction of nucleosome positions
Guocheng Yuan, Harvard School of Public Health
June 11, 2008: Histone modifications and signaling
Session Chair: Sergei Grigoryev
Morning:
9:30 - 11:00 Inter-nucleosome interactions in chromatin higher-order packing
Sergei Grigoryev, Penn State University College of Medicine
11:00 - 12:00 The SAGA of Histone Modifications
Patrick Grant, University of Virginia
12:00 - 1:30 Lunch Break
Afternoon:
1:30 - 2:30 Diversity in Chromatin Docking Interactions of Chromodomains
Sepideh Khorasanizadeh, University of Virginia
2:30 - 3:30 Mix and Match: Landscaping Chromatin during Transcription
Thomas Kusch, Rutgers University
3:30 - 5:30 Poster Session
June 12, 2008: Chromatin remodeling and transitions
Session Chair: David Clark
Morning:
9:30 - 11:00 Gene Activation in Yeast: Chromatin Remodeling and Nucleosome Dynamics
David Clark, NIH
11:00 - 12:00 Mechanism of nucleosome survival and chromatin
remodeling during transcription by Pol II
Vasily Studitsky, UMDNJ
12:00 - 1:30 Lunch Break
Afternoon:
1:30 - 2:30 Mechanism of ATP-dependent chromatin remodeling:
lessons from ISW2 and SWI/SNF
Blaine Bartholomew, Southern Illinois University School of Medicine
2:30 - 3:30 Histone Modification, Deposition, and Turnover
Paul Kaufman, University of Massachusetts Medical School
3:30 - 3:45 Break
3:45 - 4:45 Functional importance of Histone H4K20 methylation
Ruth Steward, Rutgers University
June 13, 2008: Programming functional chromatin states
Session Chair: Gary Felsenfeld
Morning:
9:30 - 10:30 The establishment and maintenance of chromatin boundaries
Gary Felsenfeld, NIH
10:30 - 10:45 Break
10:45 - 11:45 The Rise and Fall of Models for Heterochromatin Establishment
Marc Gartenberg, UMDNJ
11:45 - 12:45 ATP-dependent chromatin assembly
Dmitry Fyodorov, Albert Einstein College of Medicine
Afternoon:
12:45 - 1:00 Closing Remarks
Alexandre Morozov & Vasily Studitsky: Closing Remarks
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***There is no registration fee but registration is required. Please go
to the BioMaPS Summer School Website to register:
(http://www.biomaps.rutgers.edu/
index.php?option=com_content&task=blogcategory&id=22&Itemid=79)
If you have any questions on the Summer School, need travel
assistance, help in hotel accommodations or arranging for short-term
summer graduate student housing, please contact
info@biomaps.rutgers.edu.
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